phydms: software for phylogenetic analyses informed by deep mutational scanning

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phydms: software for phylogenetic analyses informed by deep mutational scanning

It has recently become possible to experimentally measure the effects of all amino-acid point mutations to proteins using deep mutational scanning. These experimental measurements can inform site-specific phylogenetic substitution models of gene evolution in nature. Here we describe software that efficiently performs analyses with such substitution models. This software, phydms, can be used to ...

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ژورنال

عنوان ژورنال: PeerJ

سال: 2017

ISSN: 2167-8359

DOI: 10.7717/peerj.3657